The role of compaction simulator equipment in formulation design

The assessment of the compaction performances pharmaceutical powders is an important aspect tablet product design, development and manufacturing. Compaction simulators have potential applications in research terms studying basic mechanisms, troubleshooting, various process variables, data library creation, scale-up parameters, fingerprinting new active ingredients (APIs) or excipients. upscaling between early R&D production can be time-consuming costly, resulting a long time-to-market shorter commercial lifecycles. Due to limited availability high price APIs during drug phases, proven highly valuable as dwell time punch speed set accurately mimic bottom upper movement on rotary press. Many issues inherent formula acquired from previous processes avoided reduced if applied correctly. However, adequate attention not paid understanding behaviour what being pressed, this may also source several other problems. Pharmaceutical scientists now use variety instrumented presses produce robust formulations. They allow conduct experiments for in-depth analysis characteristics materials with great efficiency time, expense, knowledge gained. ability anything formulation studies manufacturing troubleshooting makes them invaluable, particularly light recent Process Analytical Technology (PAT)/Ouality by design (QbD) phenomenon.